Biology Services: Contract Research Organization

Biology Services :: List of Contract Research Organizations (CRO) :: Pre-clinical CROs

Welcome to Biology CRO informational resource for life science and pharmaceutical researchers. This website provides a list of contract research organizations (CRO) that offer various pharmacology and biotechnology laboratory services to pharma/biotech industry and academic research centers.

A contract research organization or CRO is a company that provides outsourced research services, typically laboratory-based or analytical, to pharmaceutical, biotechnology or medical device manufacturers. Among the services they provide are preclinical research, development of drugs, in vitro and in vivo studies, assay development, commercialization work, and management of clinical trials.

CRO companies often work closely with research institutes, universities, governmental organizations, and other entities involved in pharmaceutical and health research. CROs vary in size from large multinational organizations with the resources for large-scale clinical trials to small companies with expertise in specific assays or processes.

CROs that maintain quality systems called good laboratory practices (GLP) or good manufacturing practices (GMP) can be used to perform studies to support regulatory filings such as Investigational New Drug (IND) applications – regulated by federal agency FDA in USA.


Molecular and Cell Biology Laboratory Services (Company):

Xenograft, Invivo toxicology service (IND), biodistribution, RNAi studies (Altogen Labs)

DNA Sequencing Services (Cofactor Genomics)

Genome analysis services (Celera)

Bioremediation Products and Services (Soil Bioremediation Inc)

Histology and mRNA arrays CRO services (GE Healthcare Life Sciences)

Microarray consulting (Arrayit Corp)

Microarray design and CRO services (GE Healthcare)

In Vivo RNA Interference (RNAi) services (Altogen Services)

Custom and modified oligo synthesis (Biosearch Technologies)

Protein microarray processing (Amersham)

Transfection products and services (Cell-Transfection Inc)

Real-time qRT-PCR validation of gene silencing (Applied Biosystems)

siRNA transfection resource (siRNA Transfection)

Liposome formulation and liposomal encapsulation (Liposome Services)

Bacterial strain construction (Wiki)

Vector construction and modification (Origene Inc)

Stable cell line development, generation of protein overexpression cell lines (Altogen Biosystems)

ATP Contamination testing (Wiki)

cDNA normalization, Competent cells, Custom Reporter gene assay (Promega)

Current Biology

Current Biology RSS feed. Current Biology is widely valued among life scientists for its unique blend of important research papers and informed, lively commentary. Published every 2 weeks, the journal delivers exciting primary research from all areas of biology, from molecular biology to evolution. Current Biology also features timely Dispatches - commentary by leading experts on the latest advances - as well as valuable full-length reviews and a vibrant magazine section that includes news, analysis and opinion, profiles of leading scientists and institutions, and informative, accessible guides to notable topics in biology.Current Biology features research and commentary in all areas of biology, including: Cell Biology, Cell Signaling, Cell Cycle Regulation, and Apoptosis Developmental Biology Cellular and Systems Neuroscience Cancer Biology Gene Expression, including Genomics & Proteomics DNA and RNA Metabolism, including Transcription and Translation Plant Biology Immunology Ecology and EvolutionCurrent Biology has earnerd a leading Impact Factor among biology journals of its scope. Visit the Current Biology website to learn more.

Crystal and Smith show that rats remember earlier episodes as distinct (i.e., bound) events or scenes, rather than as unconnected features.
Author: Jonathon D. Crystal, Alexandra E. Smith
Posted: November 20, 2014, 12:00 am
The regulation of nuclear morphology is poorly understood. In budding yeast, a mitotic arrest induces a nuclear envelope (NE) extension (flare) adjacent to the nucleolus. Walters et al. show that in the absence of Cdc5 polo kinase activity, the nucleus expands isometrically, without forming a flare. Thus, Cdc5 is required for NE compartmentalization.
Author: Alison D. Walters, Christopher K. May, Emma S. Dauster, Bertrand P. Cinquin, Elizabeth A. Smith, Xavier Robellet, Damien D’Amours, Carolyn A. Larabell, Orna Cohen-Fix
Posted: November 20, 2014, 12:00 am
Cuturi and MacNeilage show that sustained exposure to visually simulated self-motion leads to illusory perception of passive body movement in the opposite direction in darkness. This novel crossmodal aftereffect indicates adaptive neural mechanisms generalized for multisensory self-motion processing.
Author: Luigi F. Cuturi, Paul R. MacNeilage
Posted: November 20, 2014, 12:00 am
Challenging the lay view of dominance, wherein dominant people are assumed to ignore others’ views, Cook et al. show that socially dominant people explicitly value independence but, paradoxically, in a complex decision task, show an enhanced reliance on social learning. In contrast, aggressively dominant individuals do not rely on social learning.
Author: Jennifer Louise Cook, Hanneke E.M. den Ouden, Cecilia M. Heyes, Roshan Cools
Posted: November 20, 2014, 12:00 am
Norman et al. test the effects of invisible masked primes on judgments of the color of a stimulus seen under different illumination. A prime matching the stimulus in surface properties, the way it reflects light, speeds responses more than one matching in spectral composition of light. Color constancy cannot depend on color sensation.
Author: Liam J. Norman, Kathleen Akins, Charles A. Heywood, Robert W. Kentridge
Posted: November 20, 2014, 12:00 am
How does object-based attention spread over an object? Pooresmaeili and Roelfsema record neuronal activity in area V1 of monkeys during contour grouping and observe the gradual propagation of enhanced activity over a curve. Propagation speed depends on the distance between curves, in support of a growth-cone model of object-based attention.
Author: Arezoo Pooresmaeili, Pieter R. Roelfsema
Posted: November 20, 2014, 12:00 am
Zaldivar et al. show dissociation of BOLD and neural signals in macaque primary visual cortex after systemic DA injection. The CBF increase, along with the neural activity, suggests this is driven by increased energy use. A lack of change upon local DA application indicates this was not locally induced but was the result of remote influence.
Author: Daniel Zaldivar, Alexander Rauch, Kevin Whittingstall, Nikos K. Logothetis, Jozien Goense
Posted: November 20, 2014, 12:00 am
Vision requires sophisticated computation to convert photoreceptor output to behavior. Fenk et al. show that flies need motion-sensitive T4-T5 cells for some types of object responses. Neurons immediately downstream of T4-T5 cells are involved in wide-field stabilization, but their modeling shows that such neurons may also mediate object responses.
Author: Lisa M. Fenk, Andreas Poehlmann, Andrew D. Straw
Posted: November 13, 2014, 12:00 am
In a study of wild chimpanzees, Feldblum et al. present the first evidence of the genetic effects of male-female aggression in mammals. Aggression toward sexually receptive females increased male mating success, but only aggression toward non-sexually receptive females increased male paternity odds. This effect was strongest for high-ranking males.
Author: Joseph T. Feldblum, Emily E. Wroblewski, Rebecca S. Rudicell, Beatrice H. Hahn, Thais Paiva, Mine Cetinkaya-Rundel, Anne E. Pusey, Ian C. Gilby
Posted: November 13, 2014, 12:00 am
Hughes et al. show that extinction risk in species of corals and reef fish is rarely elevated by double jeopardy because the geographic ranges of species vary independently of their numerical abundance. Even if global extinction risks are low, conservation efforts are urgently needed to maintain and rebuild ecological functions on coral reefs.
Author: Terry P. Hughes, David R. Bellwood, Sean R. Connolly, Howard V. Cornell, Ronald H. Karlson
Posted: November 13, 2014, 12:00 am
Intergroup conflict is thought to be a key factor driving the evolution of sociality. Radford and Fawcett find that territorial conflicts between rival groups of green woodhoopoes, a cooperatively breeding bird, promote social bonding, group cohesion, and joint defense of critical roost sites many hours later.
Author: Andrew N. Radford, Tim W. Fawcett
Posted: November 13, 2014, 12:00 am
The suprachiasmatic nucleus houses the master circadian clock, but local clocks are also found in many cells. It is unclear what local brain clocks do. Yu et al. reveal that a local clock in histaminergic neurons determines fluctuations of the “wakefulness transmitter” histamine, thus balancing sleep and wake within the animal’s circadian behavior.
Author: Xiao Yu, Anna Zecharia, Zhe Zhang, Qianzi Yang, Raquel Yustos, Polona Jager, Alexei L. Vyssotski, Elizabeth S. Maywood, Johanna E. Chesham, Ying Ma, Stephen G. Brickley, Michael H. Hastings, Nicholas P. Franks, William Wisden
Posted: November 13, 2014, 12:00 am
Memory allocation is the process that determines which specific neurons in a neural network will store a given memory. Previously, memory allocation was studied in the amygdala. Here, Sano et al. showed that CREB plays a critical role in the allocation of conditioned taste aversion memory in the insular cortex.
Author: Yoshitake Sano, Justin L. Shobe, Miou Zhou, Shan Huang, Tristan Shuman, Denise J. Cai, Peyman Golshani, Masakazu Kamata, Alcino J. Silva
Posted: November 13, 2014, 12:00 am
Tapia and Koshland show that trehalose is essential for long-term desiccation tolerance in yeast. Trehalose mitigates desiccation-induced proteotoxicity of aggregation-prone membrane and cytoplasmic proteins. These studies provide insights into the in vivo potential of small chemical chaperones to act as stable and versatile stress effectors.
Author: Hugo Tapia, Douglas E. Koshland
Posted: November 13, 2014, 12:00 am
Scott et al. show that neurons in higher-order auditory cortex display excitatory and suppressive modulations during the retention of a sound in short-term memory. The dynamics of excitatory modulation mirror behavioral performance, revealing a neuronal correlate of interference effects that degrades the memory trace.
Author: Brian H. Scott, Mortimer Mishkin, Pingbo Yin
Posted: November 13, 2014, 12:00 am
Old people have more-faithful mental representations of facial age, whereas young people have an underdeveloped mental representation that divides the age spectrum into young (like them) and old (everyone else). van Rijsbergen et al. demonstrate that the older mind depicts socially relevant information more accurately than its younger counterpart.
Author: Nicola van Rijsbergen, Katarzyna Jaworska, Guillaume A. Rousselet, Philippe G. Schyns
Posted: November 13, 2014, 12:00 am
Viaene et al. show in the moss Physcomitrella patens that PIN-mediated auxin transport mediates crucial developmental transitions in tip-growing filaments and waves of polarization and differentiation in leaf-like structures.
Author: Tom Viaene, Katarina Landberg, Mattias Thelander, Eva Medvecka, Eric Pederson, Elena Feraru, Endymion D. Cooper, Mansour Karimi, Charles F. Delwiche, Karin Ljung, Markus Geisler, Eva Sundberg, Jiří Friml
Posted: November 13, 2014, 12:00 am
Shooting systems have undergone 450 million years of independent evolution in flowering plant sporophytes and bryophyte gametophytes. Bennett et al. show that PIN-mediated auxin transport regulates shoot development in both life cycle stages in a moss and identify potential roles for PIN proteins in the evolution of plant body plans.
Author: Tom A. Bennett, Maureen M. Liu, Tsuyoshi Aoyama, Nicole M. Bierfreund, Marion Braun, Yoan Coudert, Ross J. Dennis, Devin O’Connor, Xiao Y. Wang, Chris D. White, Eva L. Decker, Ralf Reski, C. Jill Harrison
Posted: November 13, 2014, 12:00 am
Robbirt et al. showed that warmer springs have led to advancement of flight date in male bees that are sexually deceived into pollinating the flowers of an orchid. Comparison of flight advancement with advancement of orchid flowering date indicates that there will be progressive disruption of this specific pollination system with climatic warming.
Author: Karen M. Robbirt, David L. Roberts, Michael J. Hutchings, Anthony J. Davy
Posted: November 6, 2014, 12:00 am
Ala-Laurila and Rieke show that the retina provides the brain with two fundamentally different readouts of the rod’s single-photon responses: a low-noise, thresholded readout (On ganglion cells) and a noisy, linear readout (Off ganglion cells). This resolves a long-standing debate about the neural substrates for absolute visual sensitivity.
Author: Petri Ala-Laurila, Fred Rieke
Posted: November 6, 2014, 12:00 am
Cannon et al. use transcriptomic data to resolve relationships of hemichordates and echinoderms, Ambulacraria. Pterobranchs are sister to acorn worms, and deep-sea torquaratorids are derived ptychoderid acorn worms. An asteroid/ophiuroid clade is supported. These results aid understanding of deuterostome model systems and the fossil record.
Author: Johanna T. Cannon, Kevin M. Kocot, Damien S. Waits, David A. Weese, Billie J. Swalla, Scott R. Santos, Kenneth M. Halanych
Posted: November 6, 2014, 12:00 am
Nadkarni and Brieher show that Aip1 is a cofilin-dependent actin disassembly factor that destabilizes filaments even in the presence of stabilizing amounts of cofilin. Filaments depolymerize by increased severing and depolymerization from ends. They also show that Aip1 is not a high-affinity barbed-end-capping protein as was previously described.
Author: Ambika V. Nadkarni, William M. Brieher
Posted: November 6, 2014, 12:00 am
Local mate competition (LMC) mediates the intensity of sexual conflict over sex ratio in haplodiploid species, with more intense conflicts under low levels of LMC. Through an experimental evolution approach, Macke et al. show that in such a conflictual situation, both sexes evolve manipulative traits to shift the sex ratio to their own advantage.
Author: Emilie Macke, Isabelle Olivieri, Sara Magalhães
Posted: October 30, 2014, 12:00 am
Zhu et al. find that egg-laying female fruit flies avoid UV, otherwise attractive, and that different egg-laying-induced aversive maneuvers are controlled by different second-order visual neurons. This suggests that egg-laying demand can modify sensory-motor transformation in fruit flies, enabled by their built-in parallel UV-processing pathways.
Author: Edward Y. Zhu, Ananya R. Guntur, Ruo He, Ulrich Stern, Chung-Hui Yang
Posted: October 30, 2014, 12:00 am